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LORBRIQUA® (lorlatinib) is indicated for the treatment of adult patients with ALK+ metastatic NSCLC.1

Oedema

Therapy management guidance for oedema1-3

  • Prior to LORBRIQUA® (lorlatinib) dose modification, consider the following to manage low-grade oedema in patients treated with LORBRIQUA®:
      
    • Compression stockings
       
    • Leg elevation
       
    • Lifestyle modifications (increased exercise and limiting dietary salt intake)
       
    • Diuretics (usually furosemide)
       
  • If oedema persists or worsens, follow general dose modification guidance for LORBRIQUA® until:
     
    • Oedema resolves to Grade ≤2
      ​​​​​​​ 
    • Oedema resolves to baseline; rechallenge with a reduced dose
       
  • ​​​​​​​​​​​​​​​​​​​​​In the CROWN trial, oedema led to dose interruptions in 5% of patients and dose reductions in 5% of patients
    ​​​​​​​
  • ​​​​​​​Oedema was the most common cause of dose interruptions (7%) and dose reductions (6%) in the Phase 1/2 trial​​​​​​​

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H4 (Mobile)


*Grade based on the NCI CTCAE version 4.03.


ALK+, anaplastic lymphoma kinase-positive; CTCAE, Common Terminology Criteria for Adverse Events; NCI, National Cancer Institute; NSCLC, non-small cell lung cancer.


References:Lorbriqua. Local product document. Pfizer; 2021. LPD Version 7.0  LPDLOR102022.Bauer TM, Felip E, Solomon BJ, et al. Clinical management of adverse events associated with lorlatinib. Oncologist. 2019;24(8):1103-1110.Reed M, Rosales ALS, Chioda MD, Parker L, Devgan G, Kettle J. Consensus recommendations for management and counseling of adverse events associated with lorlatinib: a guide for healthcare practitioners. 
Adv Ther. 2020;37(6):3019-3030.


Please click the Prescribing Information link to view the safety and adverse events information of LORBRIQUA®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.​​​​​​


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