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LORBRIQUA® (lorlatinib) is indicated for the treatment of adult patients with ALK+ metastatic NSCLC.1

ILD/Pneumonitis

  • In the pooled data from the CROWN and Phase 1/2 trials, 4 patients (0.8%) discontinued LORBRIQUA® (lorlatinib) due to ILD/pneumonitis1
     
  • It is suggested to promptly investigate for ILD/pneumonitis in any patient who presents with worsening of respiratory symptoms which is indicative of ILD/pneumonitis (e.g. dyspnoea, cough and fever)1

Dosage modification guidance for ILD/pneumonitis1

  • Immediately withhold LORBRIQUA® in patients with suspected ILD/pneumonitis
     
  • Permanently discontinue LORBRIQUA® for treatment-related ILD/pneumonitis of any severity

The data in the Warnings and Precautions section of the Prescribing Information reflect exposure to LORBRIQUA® in 476 patients who received 100-mg LORBRIQUA® QD in Study B7461001 (N=327) and Study B7461006 (N=149).1

   

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H4 (Mobile)

   

ALK+, anaplastic lymphoma kinase-positive; ILD, interstitial lung disease; NSCLC, non-small cell lung cancer; QD, once a day.

   

Reference: 

Lorbriqua. Local product document. Pfizer; 2021. LPD Version 7.0  LPDLOR102022.

   

Please click the Prescribing Information link to view the safety and adverse events information of LORBRIQUA®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.​​​​​​

   

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