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LORBRIQUA® (lorlatinib) is indicated for the treatment of adult patients with ALK+ metastatic NSCLC.1

Safety Overview

CROWN trial safety overview2,3

  

The percentage of patients who continued to receive the trial treatment for at least 12 months was 76% in the lorlatinib group and 35% in the crizotinib group

  

Adapted from Solomon B, et al. 2020.

Incidence and risk of AE-related outcome measures1,2

  

  

  

*Estimated using the Kaplan-Meier method.
†Two deaths in the lorlatinib group were reported possibly due to the study treatment by the investigators.

  

AE, adverse event; ALK+, anaplastic lymphoma kinase-positive; CI, confidence interval; ESMO, European Society for Medical Oncology; NE, not estimable; NSCLC, non-small cell lung cancer.

  

References:

Lorbriqua. Local product document. Pfizer; 2021. LPD Version 7.0  LPDLOR102022.Shaw AT, Bauer TM, de Marinis F, et al; CROWN Trial Investigators. First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. N Engl J Med. 2020;383(21):2018-2029.Solomon B, Bauer TM, De Marinis F, et al. LBA2 - Lorlatinib vs crizotinib in the first-line treatment of patients (pts) with advanced ALK-positive non-small cell lung cancer (NSCLC): results of the phase 3 CROWN study. Paper presented at: European Society for Medical Oncology (ESMO) Virtual Congress; September 19-21, 2020. Accessed March 15, 2016. https://oncologypro.esmo.org/meeting-resources/esmo-virtual-congress-2020/lorlatinib-vs-crizotinib-in-the-first-line-treatment-of-patients-pts-with-advanced-alk-positive-non-small-cell-lung-cancer-nsclc-results-of-th

  

Please click the Prescribing Information link to view the safety and adverse events information of LORBRIQUA®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.​​​​​​

  

PP-LOR-IND-0129 June 2022

Efficacy & Safety

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American Cancer Society

The American Cancer Society funds and conducts research, shares expert information and provides support for patients who have been affected by cancer.

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Lung Cancer Foundation of America

The Lung Cancer Foundation of America aims to improve the survivorship of patients with lung cancer through the funding of transformative science.

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For more details on, Who is a Registered medical practitioner*, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April 2021.
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