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LORBRIQUA® (lorlatinib) is indicated for the treatment of adult patients with ALK+ metastatic NSCLC.1
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Progression-free Survival & Objective Response Rate

Primary Endpoint: PFS by BICR2

Adapted from Shaw AT, et al. 2020.  ORR by BICR2Response duration ≥12 months: 70% with LORBRIQUA® versus 27% with crizotinib2  

Adapted from Shaw AT, et al. 2020.
  

ORR in the Intention-to-Treat Population2

  • Similar response rates were obtained based on the investigator assessment
  

ALK+, anaplastic lymphoma kinase-positive; BICR, blinded independent central review; CI, confidence interval; CR, complete response; DoR, duration of response; HR, hazard ratio; IQR, interquartile range; NE, not evaluable; NR, not reached; NSCLC, non-small cell lung cancer; OR, odds ratio; ORR, objective response rate; PD, progressive disease; PFS, progression-free survival; PR, partial response; SD, stable disease.

     

References:

Lorbriqua. Local product document. Pfizer; 2021. LPD Version 7.0  LPDLOR102022.Shaw AT, Bauer TM, de Marinis F, et al. CROWN Trial Investigators. First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. N Engl J Med. 2020;383(21):2018-2029.  

Please click the Prescribing Information link to view the safety and adverse events information of LORBRIQUA®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.​​​​​​

    

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Efficacy & Safety

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