Neuroprotective effects have been shown in both the PNS and the CNS in both animal and clinical studies2
Protection against neurodegeneration and Alzheimer disease in a mouse model2
In ATTR-CM, a TTR gene mutation or age-related changes destabilise the protein tetramers, which separate into monomers and then misfold and aggregate into amyloid fibrils that deposit in the heart and other organs over time.2,4
Because amyloid fibrils can deposit in different parts of the body, including the heart and nerves, some patients may present with a mixed phenotype, namely, symptoms of both cardiomyopathy and polyneuropathy.2,5
Suspicion of cardiac involvement should prompt an immediate cardiac evaluation to rule out ATTR-CM.6
Gain a deeper understanding of echo and CMR.
Review the evidence and consensus recommendations for diagnosis.
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For more details on, Who is a Registered medical practitioner*, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April 2021.
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